Raloxifene Hydrochloride Powder ke eng le ts'ebeliso ea eona?

Raloxifene hydrochloride phofo ke sekhetho sa estrogen receptor modulator (SERM) se 'nileng sa sebelisoa haholo ho phekola maemo a sa tšoaneng, haholo-holo ho basali ba postmenopausal. Motsoako ona o fumane tlhokomelo e kholo ka lebaka la bokhoni ba ona ba ho etsisa litlamorao tsa estrogen bophelong ba masapo le pelo ha o ntse o fokotsa likotsi tse ka bang teng tse amanang le kalafo ea estrogen, joalo ka mofetše oa matsoele le endometrial hyperplasia. Ka poso ena e pharaletseng ea blog, re tla hlahloba mofuta oa raloxifene hydrochloride powder, mekhoa ea eona ea ts'ebetso, le mekhoa ea eona e sa tšoaneng lefapheng la tlhokomelo ea bophelo.

Mokhoa oa ho sebetsa oa Raloxifene Hydrochloride Powder ke ofe?

Raloxifene hydrochloride phofo e hlahisa liphello tsa eona ka ho khetha ho tlama li-receptor tsa estrogen (ERs) ka har'a lisele tse lebisitsoeng. Leha ho le joalo, ho fapana le phekolo ea estrogen ea setso, raloxifene e sebetsa e le ER agonist kapa mohanyetsi ho itšetlehile ka mofuta oa lisele. Litabeng tsa masapo, raloxifene e bonts'a thepa ea agonistic, e khothalletsang mosebetsi oa osteoblasts (lisele tse hahang masapo) le ho thibela li-osteoclasts (lisele tse senyang masapo). Mokhoa ona o thusa ho boloka masapo le ho fokotsa kotsi ea lefu la masapo le ho robeha ha basali ba postmenopausal.

Ka lehlakoreng le leng, ka matsoele le liseleng tsa uterine, raloxifene e sebetsa e le mohanyetsi oa ER, e thibela liphello tse ngata tsa estrogen. Thepa ena e molemo haholo ho fokotsa kotsi ea kankere ea matsoele e itšetlehileng ka li-hormone le hyperplasia ea endometrial. Ho phaella moo, raloxifene e bontšitsoe hore e na le liphello tse ntle ho metabolism ea lipid, e ka 'nang ea fokotsa kotsi ea lefu la pelo ka ho ntlafatsa boemo ba lipid.

The selective modulation of estrogen receptors by raloxifene hydrochloride phofo e lumella mokhoa o lebisitsoeng oa ho sebetsana le mathata a sa tšoaneng a bophelo bo botle a amanang le khaello ea estrogen ha ho ntse ho fokotsa liphello tse mpe tse ka 'nang tsa e-ba teng tsa phekolo ea ho fetola lihomone tse tloaelehileng.

Litšebeliso tse Amoheletsoeng tsa Raloxifene Hydrochloride Powder ke life?

Tšebeliso e ka sehloohong e amohelehang ea raloxifene hydrochloride phofo ke bakeng sa thibelo le phekolo ea lefu la masapo ho basali ba postmenopausal. Liteko tsa meriana li bontšitse hore raloxifene e eketsa ka katleho masapo a masapo (BMD) le ho fokotsa kotsi ea ho robeha ha lesapo la mokokotlo ho baahi bana. Ho feta moo, raloxifene e bontšitsoe ho fokotsa kotsi ea kankere ea matsoele e hlaselang ho basali ba postmenopausal ba nang le lefu la ho fokola ha masapo le ba kotsing e kholo ea kankere ea matsoele e hlaselang.

Ntle le ts'ebeliso ea eona ea ho thibela lefu la masapo le ho thibela mofetše oa matsoele, raloxifene hydrochloride phofo e batlisisitsoe ka tšebeliso ea eona e ka bang teng maemong a mang. Liphuputso tse ling li bontšitse hore raloxifene e ka 'na ea e-ba le liphello tse molemo ho bophelo bo botle ba pelo ka ho ntlafatsa litlaleho tsa lipid le ho fokotsa kotsi ea liketsahalo tsa lefu la pelo ho basali ba postmenopausal ba nang le likotsi tse eketsehileng.

Le hoja e se pontšo e amohelehang, bafuputsi ba boetse ba hlahlobile tšebeliso ea raloxifene ho phekola mafu a matsoele a kotsi, a kang maemo a sefuba a fibrocystic le bohloko ba matsoele. Leha ho le joalo, lipatlisiso tse ling lia hlokahala ho tiisa katleho le polokeho ea eona lits'ebetsong tsena.

Liphello le Litlhokomelo tse ka bang teng ka Raloxifene Hydrochloride Powder ke life?

Joalo ka meriana efe kapa efe, tšebeliso ea raloxifene hydrochloride phofo e amahanngoa le litla-morao tse ka bang teng le litemoso. E 'ngoe ea litla-morao tse atileng haholo tse tlalehiloeng litekong tsa bongaka ke li-hot flash, tse ka tšoenyang basali ba bang. Litla-morao tse ling li ka kenyelletsa mahlaba a leoto, edema ea peripheral (ho ruruha), le kotsi e eketsehileng ea liketsahalo tsa venous thromboembolic (joalo ka thrombosis e tebileng ea methapo le pulmonary embolism).

Ke habohlokoa ho hlokomela hore raloxifene ha ea lokela ho sebelisoa ho basali ba nang le histori e sebetsang kapa e fetileng ea liketsahalo tsa venous thromboembolic, kaha e ka eketsa kotsi ea ho khutla hape. Ho phaella moo, raloxifene e hanyetsanoa ho basali ba nang le lefu la sebete kapa ho tsoa mali a sa hlalosoang a uterine.

Bakuli ba nkang raloxifene hydrochloride phofo ba lokela ho hlahlojoa khafetsa matsoele le mammograms, kaha lithethefatsi li ka eketsa kotsi ea kankere ea matsoele ho batho ba bang. Ho lekoa ka hloko ha methapo ea masapo le profil ea lipids e khothaletsoa nakong ea kalafo.

Ke habohlokoa hore litsebi tsa tlhokomelo ea bophelo li hlahlobe ka hloko melemo le likotsi tse ka 'nang tsa e-ba teng tsa phekolo ea raloxifene bakeng sa mokuli e mong le e mong, ho nahana ka histori ea bona ea bongaka, mabaka a kotsi, le boemo ba bophelo bo botle ka kakaretso.

fihlela qeto e

Raloxifene hydrochloride phofo e hlahile e le khetho ea bohlokoa ea phekolo bakeng sa basali ba postmenopausal, e fanang ka mokhoa o ikhethang oa ho sebetsana le mathata a sa tšoaneng a bophelo bo amanang le khaello ea estrogen. Mehaho ea eona e khethollang ea estrogen receptor modulation e etsa hore e be molemo ka ho khetheha thibelong le kalafong ea lefu la ho fokola ha masapo le ho fokotsa kotsi ea mofetše oa matsoele o hlaselang. Leha ho le joalo, ho bohlokoa ho nahana ka hloko litla-morao le litemoso tse amanang le tšebeliso ea eona, le ho beha bakuli leihlo nakong ea kalafo. Joalo ka meriana efe kapa efe, tlhahlobo e felletseng ea melemo ea kotsi e lokela ho etsoa ke litsebi tsa tlhokomelo ea bophelo ho netefatsa polokeho le katleho ea kalafo ea raloxifene bakeng sa bakuli ka bomong.

Haeba le uena u thahasella sehlahisoa sena 'me u batla ho tseba lintlha tse ling tsa sehlahisoa, kapa u batla ho tseba ka lihlahisoa tse ling tse amanang le tsona, ka kopo ikutloe u lokolohile ho ikopanya le rona. iceyqiang@gmail.com.

References:

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